How to trim a text box or replace a single letter at a specific index?

I played with it and it does not work. Infact this is a very good reference

But none could do what I want. Let me reword my questions
Given a text string say 2453635656 if I want to remove the digit at index 3 5 and 8 how would I do it?
Given a text string say 2453635656 if I want to replace the digit at #3 by 2, the digit at #5 by 1 and the digit at #8 by 4 how would I do it? All I need is some hint or a nudge in the right direction and I will put the effort. Thanks